PF3D7_0806900

Genome location: Pf3D7_08_v3:368,475..370,478(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	possibly expressed	0.41	0.75
Schizont	not expressed	0.17	0.89
Gametocyte	not expressed	0.28	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0806900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.158 | MFS: -3.125 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1223700)

Relative Growth Rate: 0.08 ± 0.08
Confidence: 6.52

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWH7

"Best" AlphaFill ligand hit: DCC (dodecyl-coa, Local RMSD=0.02) with 3ANP (Global RMSD=13.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134688

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	10	7	15
disruptive	3	11	12	40
missense	3	11	10	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	16	19	24
disruptive	5	52	33	108
missense	4	34	28	73

PlasmoDB Total SNPs: 83

Non-coding: 75 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 379 | Molecular Weight (kDa): 45.155

UniProt ID(s): A0A143ZWH7

PDB ID(s): None

Isoelectric Point: 9.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A