PF3D7_0807000

Genome location: Pf3D7_08_v3:367,780..372,978(+)

Genome classification: Core

Function and Localization

Product Description: YEATS domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003700	DNA-binding transcription factor activity
Process	GO:0006355	regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.08	0.95
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0807000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.747 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1223600)

Relative Growth Rate: 0.09 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4S5

"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.18) with 5VNA (Global RMSD=2.04)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q03111	Protein ENL		OrthoMCL BLAST	CHEMBL4204545CHEMBL4217790CHEMBL4211962CHEMBL4206834...

Orthology Information

Ortholog Group (OrthoMCL): OG6_102192

Most Similar Human Ortholog: F8VTR4

TM-align score: 0.83 | RMSD: 1.98

Seq Identity: 0.36 | Length: 109 / 222

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000127337	YEATS domain containing 4

Protein Information

Protein Length: 222 | Molecular Weight (kDa): 26.082

UniProt ID(s): C0H4S5

PDB ID(s): None

Isoelectric Point: 6.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005033	YEATS
PFam	PF03366	YEATS
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	8	7	12
disruptive	1	9	2	20
missense	1	9	2	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	9	14
disruptive	3	27	20	43
missense	1	22	15	29

PlasmoDB Total SNPs: 64

Non-coding: 64 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0