PF3D7_0807200

Genome location: Pf3D7_08_v3:377,439..379,755(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.03	0.99
Trophozoite	expressed	0.10	0.93
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0807200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.506 | MFS: -0.843 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4S6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	17	13	22
disruptive	1	29	19	45
missense	1	27	19	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	42	14	28
disruptive	8	72	27	84
missense	4	58	24	63

PlasmoDB Total SNPs: 171

Non-coding: 164 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 414 | Molecular Weight (kDa): 48.862

UniProt ID(s): C0H4S6

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A