Product Description: ras-related protein Rab-18
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.5.2 (Small monomeric GTPase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0007264 | small GTPase mediated signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.27 | 0.86 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.25 | 0.83 |
| Gametocyte | possibly expressed | 0.21 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0807300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.031 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7K6B0
"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=0.09) with 1S8F (Global RMSD=1.58)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.5.2 | small monomeric GTPase | GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101993
Most Similar Human Ortholog: A0A804HL33
TM-align score: 0.94 | RMSD: 0.55
Seq Identity: 0.51 | Length: 45 / 201
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099246 | RAB18, member RAS oncogene family |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 4 | 12 |
| disruptive | 1 | 1 | 1 | 2 |
| missense | 1 | 1 | 1 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 9 | 10 |
| disruptive | 2 | 7 | 9 | 38 |
| missense | 1 | 4 | 4 | 25 |
PlasmoDB Total SNPs: 265
Non-coding: 257 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 201 | Molecular Weight (kDa): 23.163
PDB ID(s): None
Isoelectric Point: 7.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001806 | Small GTPase |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00071 | Small GTPase |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12657463 | The Plasmodium falciparum family of Rab GTPases. | Quevillon E, Spielmann T, ..., Langsley G | 10.1016/s0378-1119(03)00381-0 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 38412149 | Leishmania highjack host lipid body for its proliferation in macrophages by overexpressing host Rab18 and TRAPPC9 by downregulating miR-1914-3p expression | Sood C, Verma JK, ..., Mukhopadhyay A | 10.1371/journal.ppat.1012024 |