Product Description: coenzyme Q-binding protein COQ10 homolog, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0048039 | ubiquinone binding |
| Process | GO:0006744 | ubiquinone biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.17 | 0.89 |
| Schizont | no data | 0.38 | 0.77 |
| Gametocyte | no data | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0807400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -2.867 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1223200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1223200)
Modification: Disrupted | RMgm-4266
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4S7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102109
Most Similar Human Ortholog: Q96MF6
TM-align score: 0.76 | RMSD: 2.40
Seq Identity: 0.18 | Length: 161 / 191
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115520 | coenzyme Q10B |
| ENSG00000135469 | coenzyme Q10A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 2 | 9 |
| disruptive | 4 | 9 | 3 | 11 |
| missense | 4 | 9 | 3 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 5 | 18 |
| disruptive | 6 | 22 | 9 | 45 |
| missense | 5 | 16 | 8 | 30 |
PlasmoDB Total SNPs: 169
Non-coding: 167 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 191 | Molecular Weight (kDa): 23.274
UniProt ID(s): C0H4S7
PDB ID(s): None
Isoelectric Point: 9.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF55961 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27015086 | Characterization of a Plasmodium falciparum Orthologue of the YeastUbiquinone-Binding Protein, Coq10p. | Jenkins BJ, Daly TM, ..., Bergman LW | 10.1371/journal.pone.0152197 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |