PF3D7_0807600

Genome location: Pf3D7_08_v3:388,027..395,335(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.16	0.50
Trophozoite	expressed	1.35	0.36
Schizont	expressed	0.64	0.63
Gametocyte	expressed	0.73	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0807600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.592 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1223000)

Modification: Disrupted | RMgm-3288

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4S8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121475

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	35	51	27	40
disruptive	139	231	83	179
missense	45	110	46	106

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	44	83	34	68
disruptive	206	366	119	277
missense	66	205	63	162

PlasmoDB Total SNPs: 576

Non-coding: 213 | Synonymous: 217 | Nonsynonymous: 146 | Stop Codon: 0

Protein Information

Protein Length: 1334 | Molecular Weight (kDa): 159.032

UniProt ID(s): C0H4S8, Q2KNU9, Q2KNV0, Q2KNV2

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
28288121	A genetic system to study Plasmodium falciparum protein function.	Birnbaum J, Flemming S, ..., Spielmann T	10.1038/nmeth.4223