PF3D7_0808000

Genome location: Pf3D7_08_v3:404,225..409,140(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.43	0.76
Schizont	possibly expressed	0.12	0.92
Gametocyte	not expressed	0.44	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0808000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.786 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1222700)

Relative Growth Rate: 0.75 ± 0.17
Confidence: 4.99

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1222700)

Modification: Disrupted | RMgm-3287

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4S9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	52	21	77
disruptive	82	150	68	167
missense	39	109	53	138

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	94	36	73
disruptive	132	293	141	279
missense	67	208	98	170

PlasmoDB Total SNPs: 257

Non-coding: 52 | Synonymous: 126 | Nonsynonymous: 78 | Stop Codon: 1

Protein Information

Protein Length: 1362 | Molecular Weight (kDa): 163.921

UniProt ID(s): C0H4S9

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A