PF3D7_0808100

Genome location: Pf3D7_08_v3:409,306..415,756(+)

Genome classification: Core

Function and Localization

Product Description: AP-3 complex subunit delta, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030123	AP-3 adaptor complex
Component	GO:0010008	endosome membrane
Process	GO:0006896	Golgi to vacuole transport
Process	GO:0006886	intracellular protein transport
Process	GO:0006623	protein targeting to vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.92
Trophozoite	possibly expressed	0.68	0.62
Schizont	not expressed	0.37	0.77
Gametocyte	not expressed	0.42	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0808100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.133 | MFS: -3.156 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1222600)

Relative Growth Rate: 0.01 ± 0.05
Confidence: 7.28

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4T0

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=5.81) with 2PML (Global RMSD=18.04)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532464

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	23	52	39	68
disruptive	54	118	74	183
missense	51	112	71	160

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	105	43	86
disruptive	85	233	129	245
missense	68	202	116	187

PlasmoDB Total SNPs: 329

Non-coding: 192 | Synonymous: 74 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1609 | Molecular Weight (kDa): 193.08

UniProt ID(s): C0H4T0

PDB ID(s): None

Isoelectric Point: 8.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR017105	Adaptor protein complex AP-3, delta subunit
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold