About Gene List

PF3D7_0808450 (MPODD)

Genome location: Pf3D7_08_v3:424,794..425,171(-)

Genome classification: Core

Function and Localization

Product Description: protein MPODD, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0045273 respiratory chain complex II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data nd nd
Trophozoite no data nd nd
Schizont no data nd nd
Gametocyte no data nd nd

More info:

Resistome Mutations

No corresponding Pf3D7v3 gene ID in resistome database

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1225400)

Modification: Tagged | RMgm-4504

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8M7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_223053

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 2 1 5
disruptive 2 10 2 4
missense 2 8 2 3

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 3 2 4
disruptive 6 19 2 13
missense 4 13 1 9

PlasmoDB Total SNPs: 30

Non-coding: 17 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 2

Protein Information

Protein Length: 90 | Molecular Weight (kDa): 10.581

UniProt ID(s): A0A5K1K8M7

PDB ID(s): None

Isoelectric Point: 10.3

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
27053680 A small mitochondrial protein present in myzozoans is essential for malariatransmission. Klug D, Mair GR, Frischknecht F, Douglas RG 10.1098/rsob.160034
34155201 Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. Evers F, Cabrera-Orefice A, ..., Kooij TWA 10.1038/s41467-021-23919-x
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21