PF3D7_0809200 (pfa55-14)

Genome location: Pf3D7_08_v3:467,507..472,481(-)

Genome classification: Core

Function and Localization

Product Description: asparagine-rich antigen Pfa55-14

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000139	Golgi membrane
Function	GO:0004402	histone acetyltransferase activity
Function	GO:0004596	peptide alpha-N-acetyltransferase activity
Process	GO:0017196	N-terminal peptidyl-methionine acetylation
Process	GO:0043966	histone H3 acetylation
Process	GO:0043967	histone H4 acetylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.36	0.83
Trophozoite	possibly expressed	0.58	0.66
Schizont	not expressed	0.19	0.88
Gametocyte	expressed	1.08	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0809200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.513 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1428100)

Modification: Disrupted | RMgm-3878

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAS8

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.05) with 6JWR (Global RMSD=25.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532706

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	32	20	54
disruptive	63	121	69	182
missense	45	101	59	139

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	84	39	65
disruptive	115	286	146	359
missense	75	216	115	211

PlasmoDB Total SNPs: 271

Non-coding: 73 | Synonymous: 124 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 1316 | Molecular Weight (kDa): 156.871

UniProt ID(s): Q03632, Q2KNS7, Q8IAS8

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
PFam	N/A	N/A
Superfamily	SSF55729	Acyl-CoA N-acyltransferase