PF3D7_0809400

Genome location: Pf3D7_08_v3:475,439..478,480(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	expressed	0.79	0.58
Schizont	expressed	0.95	0.49
Gametocyte	not expressed	0.96	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0809400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.733 | MFS: -3.102 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAS9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171514

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	28	18	30
disruptive	31	70	35	83
missense	28	65	31	72

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	51	26	37
disruptive	59	137	71	162
missense	37	121	53	104

PlasmoDB Total SNPs: 83

Non-coding: 21 | Synonymous: 30 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 850 | Molecular Weight (kDa): 101.61

UniProt ID(s): Q8IAS9

PDB ID(s): None

Isoelectric Point: 8.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A