Product Description: histone acetyltransferase subunit NuA4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.48 (Histone acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070776 | MOZ/MORF histone acetyltransferase complex |
| Component | GO:1990467 | NuA3a histone acetyltransferase complex |
| Component | GO:1990468 | NuA3b histone acetyltransferase complex |
| Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Component | GO:0005730 | nucleolus |
| Process | GO:0043968 | histone H2A acetylation |
| Process | GO:0044154 | histone H3-K14 acetylation |
| Process | GO:0043983 | histone H4-K12 acetylation |
| Process | GO:0043981 | histone H4-K5 acetylation |
| Process | GO:0043982 | histone H4-K8 acetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | possibly expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0809500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.153 | MFS: -3.235 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1427900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1427900)
Modification: Disrupted | RMgm-3877
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4T2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.48 | histone acetyltransferase | CoADNARNABF1EDTAMB-3LTK14PU139A-485TTK21CPTH2CPTH6... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102943
Most Similar Human Ortholog: Q9HAF1
TM-align score: 0.61 | RMSD: 2.65
Seq Identity: 0.26 | Length: 76 / 104
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163875 | MYST/Esa1 associated factor 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 3 | 1 | 2 |
| disruptive | 0 | 5 | 2 | 6 |
| missense | 0 | 5 | 2 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 6 | 3 | 6 |
| disruptive | 1 | 12 | 7 | 15 |
| missense | 0 | 11 | 6 | 11 |
PlasmoDB Total SNPs: 36
Non-coding: 25 | Synonymous: 11 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 104 | Molecular Weight (kDa): 12.189
UniProt ID(s): C0H4T2
PDB ID(s): None
Isoelectric Point: 9.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015418 | Chromatin modification-related protein Eaf6 |
| PFam | PF09340 | Chromatin modification-related protein Eaf6 |
| Superfamily | N/A | N/A |
No associated publications