Product Description: peptidase family C50, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: 3.4.22.49 (Separase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005813 | centrosome |
Component | GO:0005737 | cytoplasm |
Component | GO:0072686 | mitotic spindle |
Component | GO:0005634 | nucleus |
Function | GO:0004197 | cysteine-type endopeptidase activity |
Process | GO:0051307 | meiotic chromosome separation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | possibly expressed | 0.13 | 0.94 |
Trophozoite | expressed | 1.02 | 0.51 |
Schizont | expressed | 0.47 | 0.74 |
Gametocyte | expressed | 1.57 | 0.32 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0809600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -2.931 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1427800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
3.4.22.49 | separase | actinCdc55astrinpeptidesecurincyclin Bsecuringsercurincyclin B1shugoshinCdk1 kinasesecurin Pds1... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 69 | 199 | 123 | 229 |
disruptive | 216 | 599 | 319 | 770 |
missense | 157 | 472 | 272 | 623 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 99 | 389 | 170 | 330 |
disruptive | 393 | 1307 | 566 | 1423 |
missense | 239 | 933 | 447 | 931 |
PlasmoDB Total SNPs: 614
Non-coding: 62 | Synonymous: 326 | Nonsynonymous: 226 | Stop Codon: 0
Protein Length: 5800 | Molecular Weight (kDa): 698.191
UniProt ID(s): C0H4T3, Q2KNP7, Q2KNQ1, Q2KNT7, Q2KNT9
PDB ID(s): None
Isoelectric Point: 8.26
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR005314 | Peptidase C50, separase |
PFam | PF03568 | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |