Product Description: JmjC domain-containing protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.14.11.27 ([Histone H3]-dimethyl-L-lysine(36) demethylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0035097 | histone methyltransferase complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0034647 | histone H3-tri/di/monomethyl-lysine-4 demethylase activity |
| Function | GO:0032452 | histone demethylase activity |
| Process | GO:0006338 | chromatin remodeling |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.52 | 0.75 |
| Trophozoite | expressed | 0.59 | 0.67 |
| Schizont | expressed | 0.32 | 0.80 |
| Gametocyte | expressed | 0.72 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0809900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.973 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAT4
"Best" AlphaFill ligand hit: MMK (2-{[(2-{[(e)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, Local RMSD=0.02) with 5ISL (Global RMSD=6.37)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O94953 | Lysine-specific demethylase 4B | OrthoDB | CHEMBL1966136CHEMBL1966136CHEMBL3775451CHEMBL3775956... | |
| Q9UGL1 | Lysine-specific demethylase 5B | OrthoDB | GSK J16-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)US9617242, Example 73KDM5-C49... | |
| P29375 | Lysine-specific demethylase 5A | Homo sapiens | OrthoDB | GSK J16-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)US9617242, Example 73KDM5-C49... |
| Q6B0I6 | Lysine-specific demethylase 4D | OrthoDB | CHEMBL1383671GSK467CHEMBL3771198CHEMBL3769724... | |
| B2RXH2 | Lysine-specific demethylase 4E | Homo sapiens | OrthoDB | pyridine carboxylate, 6abipyridine analogue, 7aromatic hydroxamic acid, 5aBaicalein, 14... |
| P41229 | Lysine-specific demethylase 5C | Homo sapiens | OrthoDB | GSK J16-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)US9617242, Example 736-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)... |
| Q9BY66 | Lysine-specific demethylase 5D | OrthoDB | 6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8)US9617242, Example 73Oxalylglycinepyridine carboxylate, 6a... | |
| O75164 | Lysine-specific demethylase 4A | OrthoDB | KDM5-C49US9738637, Example 2US9738637, Example 3US9738637, Example 7... | |
| Q9H3R0 | Lysine-specific demethylase 4C | OrthoDB | CPI-455CPI-4203KDM inhibitor, 3pyridine carboxylate, 6a... | |
| Q9Y4C1 | Lysine-specific demethylase 3A | Homo sapiens | OrthoMCL BLAST | Oxalylglycinepyridine carboxylate, 6aKDM5-C49KDM5-C49... |
Ortholog Group (OrthoMCL): OG6_100617
Most Similar Human Ortholog: F8WDK1
TM-align score: 0.70 | RMSD: 2.12
Seq Identity: 0.22 | Length: 50 / 1259
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000012817 | lysine demethylase 5D |
| ENSG00000073614 | lysine demethylase 5A |
| ENSG00000117139 | lysine demethylase 5B |
| ENSG00000126012 | lysine demethylase 5C |
Protein Length: 1259 | Molecular Weight (kDa): 149.45
UniProt ID(s): Q2KNQ8, Q2KNQ9, Q8IAT4
PDB ID(s): None
Isoelectric Point: 8.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003347 | JmjC domain |
| InterPro | IPR003349 | JmjN domain |
| InterPro | IPR004198 | Zinc finger, C5HC2-type |
| PFam | PF02373 | JmjC domain |
| PFam | PF02928 | Zinc finger, C5HC2-type |
| Superfamily | SSF51197 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 44 | 17 | 64 |
| disruptive | 39 | 137 | 65 | 185 |
| missense | 26 | 101 | 51 | 144 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 76 | 52 | 77 |
| disruptive | 83 | 283 | 171 | 400 |
| missense | 53 | 199 | 137 | 249 |
PlasmoDB Total SNPs: 253
Non-coding: 133 | Synonymous: 59 | Nonsynonymous: 61 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |