PF3D7_0810000

Genome location: Pf3D7_08_v3:517,385..518,627(-)

Genome classification: Core

Function and Localization

Product Description: acyl-CoA binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.40	0.75
Schizont	not expressed	0.09	0.93
Gametocyte	not expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.899 | MFS: -2.859 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1427500)

Relative Growth Rate: 0.97 ± 0.08
Confidence: 6.51

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAT5

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.17) with 1HBK (Global RMSD=0.55)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103494

Most Similar Human Ortholog: Q5T8D3

TM-align score: 0.90 | RMSD: 1.57

Seq Identity: 0.26 | Length: 90 / 90

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107897	acyl-CoA binding domain containing 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

PlasmoDB Total SNPs: 51

Non-coding: 49 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 90 | Molecular Weight (kDa): 10.775

UniProt ID(s): Q8IAT5

PDB ID(s): None

Isoelectric Point: 7.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000582	Acyl-CoA-binding protein, ACBP
InterPro	IPR035984	Acyl-CoA binding protein superfamily
PFam	PF00887	Acyl-CoA-binding protein, ACBP
Superfamily	SSF47027	Acyl-CoA binding protein superfamily