PF3D7_0810100

Genome location: Pf3D7_08_v3:519,144..520,724(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein L33, apicoplast, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:0000311	plastid large ribosomal subunit
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.09	0.93
Schizont	possibly expressed	0.03	0.98
Gametocyte	not expressed	0.07	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.992 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4T5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	1	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	singleton
synonymous	0	1
disruptive	1	2
missense	0	0

PlasmoDB Total SNPs: 41

Non-coding: 38 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 111 | Molecular Weight (kDa): 13.664

UniProt ID(s): C0H4T5

PDB ID(s): None

Isoelectric Point: 10.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001705	Ribosomal protein L33
InterPro	IPR011332	Zinc-binding ribosomal protein
PFam	PF00471	Ribosomal protein L33
Superfamily	SSF57829	Zinc-binding ribosomal protein