PF3D7_0810200 (ABCK1)

Genome location: Pf3D7_08_v3:521,170..524,750(+)

Genome classification: Core

Function and Localization

Product Description: ABC1 family, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Function	GO:0016301	kinase activity
Process	GO:0006744	ubiquinone biosynthetic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	possibly expressed	0.39	0.76
Schizont	not expressed	0.06	0.96
Gametocyte	expressed	0.54	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAT7

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.85) with 5YK0 (Global RMSD=9.44)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101512

Most Similar Human Ortholog: A0A7I2V544

TM-align score: 0.90 | RMSD: 1.81

Seq Identity: 0.38 | Length: 375 / 940

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000123815	coenzyme Q8B
ENSG00000163050	coenzyme Q8A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	22	20	31
disruptive	21	50	32	94
missense	13	43	29	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	53	17	50
disruptive	37	125	93	252
missense	21	93	72	163

PlasmoDB Total SNPs: 122

Non-coding: 53 | Synonymous: 48 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 940 | Molecular Weight (kDa): 111.728

UniProt ID(s): Q8IAT7

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004147	UbiB domain
InterPro	IPR011009	Protein kinase-like domain superfamily
InterPro	IPR034646	UbiB domain, ADCK3-like
PFam	PF03109	UbiB domain
Superfamily	SSF56112	Protein kinase-like domain superfamily