PF3D7_0810300 (PPM5)

Genome location: Pf3D7_08_v3:524,487..530,847(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase PPM5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.34	0.86
Trophozoite	expressed	0.72	0.62
Schizont	expressed	2.09	0.18
Gametocyte	expressed	0.83	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.05 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1427200)

Relative Growth Rate: 1.11 ± 0.17
Confidence: 4.93

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1427200)

Modification: Disrupted | RMgm-3874

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4T6

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.16	protein-serine/threonine phosphatase	ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109210

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 391

Non-coding: 362 | Synonymous: 15 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 550 | Molecular Weight (kDa): 63.62

UniProt ID(s): C0H4T6, Q2KNT3

PDB ID(s): None

Isoelectric Point: 4.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000222	PPM-type phosphatase, divalent cation binding
InterPro	IPR001932	PPM-type phosphatase domain
InterPro	IPR015655	Protein phosphatase 2C family
InterPro	IPR036457	PPM-type phosphatase domain superfamily
PFam	PF00481	PPM-type phosphatase domain
Superfamily	SSF81606	PPM-type phosphatase domain superfamily