Product Description: protein phosphatase PPM7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0008287 | protein serine/threonine phosphatase complex |
| Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Process | GO:0006470 | protein dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0810500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -2.135 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1427000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1427000)
Modification: Disrupted | RMgm-3872
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAU0
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
Orthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_101369
Most Similar Human Ortholog: Q9H0C8
TM-align score: 0.86 | RMSD: 2.27
Seq Identity: 0.28 | Length: 281 / 303
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132323 | ILK associated serine/threonine phosphatase |
| ENSG00000183032 | solute carrier family 25 member 21 |
Protein Length: 303 | Molecular Weight (kDa): 34.52
UniProt ID(s): Q8IAU0
PDB ID(s): None
Isoelectric Point: 7.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001932 | PPM-type phosphatase domain |
| InterPro | IPR015655 | Protein phosphatase 2C family |
| InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
| PFam | PF00481 | PPM-type phosphatase domain |
| Superfamily | SSF81606 | PPM-type phosphatase domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 5 | 8 | 15 |
| disruptive | 2 | 5 | 6 | 14 |
| missense | 2 | 4 | 5 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 18 | 15 | 12 |
| disruptive | 5 | 26 | 21 | 67 |
| missense | 3 | 17 | 20 | 56 |
PlasmoDB Total SNPs: 164
Non-coding: 142 | Synonymous: 18 | Nonsynonymous: 3 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 25011111 | Genome-wide functional analysis of Plasmodium protein phosphatases reveals keyregulators of parasite development and differentiation. | Guttery DS, Poulin B, ..., Tewari R | 10.1016/j.chom.2014.05.020 |