PF3D7_0810700

Genome location: Pf3D7_08_v3:545,282..547,450(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.09	0.94
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.198 | MFS: -3.331 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1426800)

Relative Growth Rate: 0.03 ± 0.09
Confidence: 6.21

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWS9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532734

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	3	1	5
disruptive	2	1	0	10
missense	2	1	0	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	3	3	5
disruptive	2	12	16	35
missense	2	9	14	21

PlasmoDB Total SNPs: 107

Non-coding: 101 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 141 | Molecular Weight (kDa): 16.804

UniProt ID(s): A0A143ZWS9

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A