PF3D7_0810900

Genome location: Pf3D7_08_v3:550,902..553,375(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	possibly expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0810900.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -3.353 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A146M1X1

"Best" AlphaFill ligand hit: IBP (2-(4-isobutylphenyl)propionic acid, Local RMSD=0.75) with 6OCI (Global RMSD=17.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533024

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	5
disruptive	2	7	2	19
missense	1	5	2	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	2	4	15
disruptive	7	34	26	61
missense	2	15	15	39

PlasmoDB Total SNPs: 114

Non-coding: 111 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 345 | Molecular Weight (kDa): 41.335

UniProt ID(s): Q8IAU4

PDB ID(s): None

Isoelectric Point: 5.68

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A