PF3D7_0811100

Genome location: Pf3D7_08_v3:557,333..560,018(-)

Genome classification: Core

Function and Localization

Product Description: mitochondrial carrier protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0015230	FAD transmembrane transporter activity
Function	GO:0008517	folic acid transmembrane transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.43	0.74
Schizont	expressed	0.25	0.83
Gametocyte	not expressed	0.26	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.734 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1426400)

Relative Growth Rate: 0.34 ± 0.04
Confidence: 7.74

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1426400)

Modification: Disrupted | RMgm-3868

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAU6

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=14.80) with 2PML (Global RMSD=18.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103707

Most Similar Human Ortholog: O43808

TM-align score: 0.81 | RMSD: 2.78

Seq Identity: 0.23 | Length: 284 / 540

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100372	solute carrier family 25 member 17

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	15	3	17
disruptive	7	13	11	25
missense	3	10	9	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	24	13	31
disruptive	12	47	38	106
missense	3	26	28	72

PlasmoDB Total SNPs: 121

Non-coding: 91 | Synonymous: 26 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 540 | Molecular Weight (kDa): 64.924

UniProt ID(s): Q8IAU6

PDB ID(s): None

Isoelectric Point: 10.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018108	Mitochondrial substrate/solute carrier
InterPro	IPR023395	Mitochondrial carrier domain superfamily
PFam	PF00153	Mitochondrial substrate/solute carrier
Superfamily	SSF103506	Mitochondrial carrier domain superfamily