About Gene List

PF3D7_0811200 (EMC1)

Genome location: Pf3D7_08_v3:560,303..564,782(+)

Genome classification: Core

Function and Localization

Product Description: ER membrane protein complex subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0072546 EMC complex
Component GO:0005783 endoplasmic reticulum
Function GO:0003723 RNA binding
Process GO:0034975 protein folding in endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.50 0.76
Trophozoite expressed 0.89 0.52
Schizont expressed 0.22 0.86
Gametocyte not expressed 0.61 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811200

Resistome Missense Mutations: S977P

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -3.234 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1426300)

  • Relative Growth Rate: 0.13 ± 0.23
  • Confidence: 4.31

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1426300)

Modification: Tagged | RMgm-780

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAU7

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.54) with 2BVL (Global RMSD=20.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102462

Most Similar Human Ortholog: H7C5A2

TM-align score: 0.66 | RMSD: 2.53

Seq Identity: 0.20 | Length: 136 / 1133

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000127463 ER membrane protein complex subunit 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 15 17 40
disruptive 39 88 46 133
missense 29 64 35 102

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 45 22 59
disruptive 68 203 103 262
missense 41 134 78 167

PlasmoDB Total SNPs: 153

Non-coding: 59 | Synonymous: 48 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 1133 | Molecular Weight (kDa): 133.759

UniProt ID(s): Q8IAU7

PDB ID(s): None

Isoelectric Point: 9.48

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011678 ER membrane protein complex subunit 1, C-terminal
InterPro IPR026895 ER membrane protein complex subunit 1
PFam PF07774 ER membrane protein complex subunit 1, C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
24841368 Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. Butler CL, Lucas O, ..., White M 10.1371/journal.pone.0097625
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21