Product Description: ER membrane protein complex subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0072546 | EMC complex |
Component | GO:0005783 | endoplasmic reticulum |
Function | GO:0003723 | RNA binding |
Process | GO:0034975 | protein folding in endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.50 | 0.76 |
Trophozoite | expressed | 0.89 | 0.52 |
Schizont | expressed | 0.22 | 0.86 |
Gametocyte | not expressed | 0.61 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0811200
Resistome Missense Mutations: S977P
Resistome Compounds with Missense Mutations: MMV982556
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.148 | MFS: -3.234 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1426300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1426300)
Modification: Tagged | RMgm-780
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAU7
"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.54) with 2BVL (Global RMSD=20.46)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102462
Most Similar Human Ortholog: H7C5A2
TM-align score: 0.66 | RMSD: 2.53
Seq Identity: 0.20 | Length: 136 / 1133
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000127463 | ER membrane protein complex subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 14 | 15 | 17 | 40 |
disruptive | 39 | 88 | 46 | 133 |
missense | 29 | 64 | 35 | 102 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 15 | 45 | 22 | 59 |
disruptive | 68 | 203 | 103 | 262 |
missense | 41 | 134 | 78 | 167 |
PlasmoDB Total SNPs: 153
Non-coding: 59 | Synonymous: 48 | Nonsynonymous: 46 | Stop Codon: 0
Protein Length: 1133 | Molecular Weight (kDa): 133.759
UniProt ID(s): Q8IAU7
PDB ID(s): None
Isoelectric Point: 9.48
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR011678 | ER membrane protein complex subunit 1, C-terminal |
InterPro | IPR026895 | ER membrane protein complex subunit 1 |
PFam | PF07774 | ER membrane protein complex subunit 1, C-terminal |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
24841368 | Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. | Butler CL, Lucas O, ..., White M | 10.1371/journal.pone.0097625 |
33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |