Product Description: CCR4-associated factor 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0030015 | CCR4-NOT core complex |
| Component | GO:0000932 | P-body |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0004535 | poly(A)-specific ribonuclease activity |
| Process | GO:0043928 | exonucleolytic catabolism of deadenylated mRNA |
| Process | GO:0017148 | negative regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 2.31 | 0.19 |
| Trophozoite | expressed | 1.44 | 0.33 |
| Schizont | expressed | 1.65 | 0.25 |
| Gametocyte | possibly expressed | 0.89 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0811300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.904 | #Insertions: 7
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1426200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1428300)
Modification: Tagged | RMgm-4593
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4T9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9UIV1 | CCR4-NOT transcription complex subunit 7 | OrthoDB | CHEMBL3616512CHEMBL3616508CHEMBL3616526CHEMBL3616525... |
Ortholog Group (OrthoMCL): OG6_101138
Most Similar Human Ortholog: E5RIU0
TM-align score: 0.98 | RMSD: 0.53
Seq Identity: 0.55 | Length: 85 / 1774
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000155508 | CCR4-NOT transcription complex subunit 8 |
| ENSG00000198791 | CCR4-NOT transcription complex subunit 7 |
Protein Length: 1774 | Molecular Weight (kDa): 200.212
UniProt ID(s): C0H4T9
PDB ID(s): None
Isoelectric Point: 7.41
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012337 | Ribonuclease H-like superfamily |
| InterPro | IPR039637 | CCR4-NOT transcription complex subunit 7/8/Pop2 |
| PFam | N/A | N/A |
| Superfamily | SSF53098 | Ribonuclease H-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 56 | 35 | 71 |
| disruptive | 43 | 149 | 78 | 192 |
| missense | 19 | 117 | 63 | 139 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 123 | 54 | 77 |
| disruptive | 78 | 383 | 207 | 608 |
| missense | 42 | 268 | 145 | 303 |
PlasmoDB Total SNPs: 343
Non-coding: 170 | Synonymous: 133 | Nonsynonymous: 40 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30703164 | Plasmodium male gametocyte development and transmission are critically regulatedby the two putative deadenylases of the CAF1/CCR4/NOT complex. | Hart KJ, Oberstaller J, ..., Lindner SE | 10.1371/journal.ppat.1007164 |
| 38407959 | A fluorescent assay for cryptic transcription in Saccharomyces cerevisiae revealsnovel insights into factors that stabilize chromatin structure on newlyreplicated DNA | Gao E, Brown JAR, Jung S, Howe LJ | 10.1093/genetics/iyae016 |
| 38287571 | Characterization of heteropolysaccharides from Rhizoctonia solani AG1 IA cellwall and comparison of their effect on inducing plant defense | Gu H, Lin Y, ..., Yin H | 10.1016/j.ijbiomac.2023.127747 |
| 38376141 | Disordered regions and folded modules in CAF-1 promote histone deposition inSchizosaccharomyces pombe | Ouasti F, Audin M, ..., Ochsenbein F | 10.7554/eLife.91461 |