PF3D7_0811400

Genome location: Pf3D7_08_v3:574,372..578,973(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.84	0.62
Trophozoite	expressed	1.29	0.38
Schizont	expressed	0.45	0.72
Gametocyte	expressed	0.42	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.847 | MFS: -2.796 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1426100)

Relative Growth Rate: 1.01 ± 0.12
Confidence: 5.71

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1426100)

Modification: Disrupted | RMgm-3865

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4U0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106962

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	7	19
disruptive	2	10	3	30
missense	2	10	3	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	29	18	27
disruptive	2	39	21	84
missense	2	26	17	55

PlasmoDB Total SNPs: 201

Non-coding: 182 | Synonymous: 16 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 608 | Molecular Weight (kDa): 71.369

UniProt ID(s): C0H4U0

PDB ID(s): None

Isoelectric Point: 5.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018553	Protein of unknown function DUF2009
PFam	PF09418	Protein of unknown function DUF2009
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596