About Gene List

PF3D7_0811500 (CARM1)

Genome location: Pf3D7_08_v3:579,007..582,905(+)

Genome classification: Core

Function and Localization

Product Description: histone-arginine methyltransferase CARM1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.125 (Transferred entry: 2.1.1.319, 2.1.1.320, 2.1.1.321 and 2.1.1.322)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0042054 histone methyltransferase activity
Process GO:0016571 histone methylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.40 0.80
Trophozoite expressed 0.29 0.83
Schizont possibly expressed 0.08 0.95
Gametocyte not expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.182 | MFS: -2.717 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1426000)

  • Relative Growth Rate: 0.84 ± 0.10
  • Confidence: 5.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1426000)

Modification: Disrupted | RMgm-3864

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K956

"Best" AlphaFill ligand hit: DXE (1,2-dimethoxyethane, Local RMSD=0.05) with 5ISE (Global RMSD=6.64)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.1.1.125 histone-arginine N-methyltransferase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139447

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 16 13 21
disruptive 17 53 42 106
missense 14 51 42 97

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 36 21 38
disruptive 32 122 72 166
missense 21 114 65 114

PlasmoDB Total SNPs: 144

Non-coding: 79 | Synonymous: 42 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 912 | Molecular Weight (kDa): 108.427

UniProt ID(s): A0A5K1K956

PDB ID(s): None

Isoelectric Point: 6.16

Protein Domain Annotations:

Source Family ID Description
InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
PFam N/A N/A
Superfamily SSF53335 S-adenosyl-L-methionine-dependent methyltransferase

Associated Publications

PMID Title Authors DOI/Link
16287846 Histone-modifying complexes regulate gene expression pertinent to thedifferentiation of the protozoan parasite Toxoplasma gondii. Saksouk N, Bhatti MM, ..., Hakimi MA 10.1128/MCB.25.23.10301-10314.2005
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108