PF3D7_0811600

Genome location: Pf3D7_08_v3:582,804..589,463(-)

Genome classification: Core

Function and Localization

Product Description: protein MAP1, putative

SignalP Peptide: MNNVIIFLLLLINFGTKVYG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Component	GO:0005634	nucleus
Component	GO:0005886	plasma membrane
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	not expressed	0.42	0.76
Schizont	expressed	1.30	0.41
Gametocyte	not expressed	0.59	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.136 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1425900)

Relative Growth Rate: 0.33 ± 0.12
Confidence: 5.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1425900)

Modification: Disrupted | RMgm-3863

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAV1

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.18) with 6A2L (Global RMSD=20.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533295

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	20	11	25
disruptive	14	27	22	68
missense	14	26	21	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	36	26	38
disruptive	24	59	51	130
missense	21	45	40	85

PlasmoDB Total SNPs: 270

Non-coding: 217 | Synonymous: 35 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 1210 | Molecular Weight (kDa): 144.008

UniProt ID(s): Q8IAV1

PDB ID(s): None

Isoelectric Point: 7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21