PF3D7_0811700

Genome location: Pf3D7_08_v3:588,248..593,489(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	1.26	0.42
Gametocyte	not expressed	0.29	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811700

Resistome Missense Mutations: E605D

Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.321 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1425800)

Modification: Disrupted | RMgm-3862

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAV2

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.64) with 3UM6 (Global RMSD=34.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532797

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	21	13	42
disruptive	27	80	45	113
missense	22	67	36	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	45	23	59
disruptive	64	182	95	243
missense	36	125	75	154

PlasmoDB Total SNPs: 95

Non-coding: 31 | Synonymous: 30 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 1222 | Molecular Weight (kDa): 147.411

UniProt ID(s): Q8IAV2

PDB ID(s): None

Isoelectric Point: 7.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A