PF3D7_0811800

Genome location: Pf3D7_08_v3:592,954..595,639(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	possibly expressed	0.67	0.62
Schizont	possibly expressed	0.14	0.90
Gametocyte	not expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.14 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1425700)

Relative Growth Rate: 0.10 ± 0.05
Confidence: 7.41

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAV3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533188

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	8	21
disruptive	26	74	27	68
missense	12	44	19	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	13	30
disruptive	66	113	45	144
missense	29	65	32	96

PlasmoDB Total SNPs: 84

Non-coding: 21 | Synonymous: 34 | Nonsynonymous: 26 | Stop Codon: 3

Protein Information

Protein Length: 587 | Molecular Weight (kDa): 71.966

UniProt ID(s): Q8IAV3

PDB ID(s): None

Isoelectric Point: 10.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A