PF3D7_0811900

Genome location: Pf3D7_08_v3:595,885..601,015(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: MLFTKIYLLFVFVLYLVSA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Function	GO:0003729	mRNA binding
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	expressed	0.88	0.55
Schizont	expressed	0.91	0.57
Gametocyte	expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0811900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.962 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1037600)

Relative Growth Rate: 0.61 ± 0.17
Confidence: 4.94

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4U1

"Best" AlphaFill ligand hit: 144 (tris-hydroxymethyl-methyl-ammonium, Local RMSD=0.79) with 4FE2 (Global RMSD=17.24)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100538

Most Similar Human Ortholog: S4R3Q4

TM-align score: 0.46 | RMSD: 2.70

Seq Identity: 0.06 | Length: 33 / 1176

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000148843	programmed cell death 11

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	23	13	51
disruptive	17	89	60	136
missense	13	77	55	122

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	47	40	61
disruptive	44	188	103	225
missense	29	162	85	178

PlasmoDB Total SNPs: 241

Non-coding: 163 | Synonymous: 49 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1176 | Molecular Weight (kDa): 140.11

UniProt ID(s): C0H4U1

PDB ID(s): None

Isoelectric Point: 6.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003029	S1 domain
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR022967	RNA-binding domain, S1
InterPro	IPR035104	Ribosomal protein S1-like
PFam	PF00575	S1 domain
Superfamily	SSF50249	Nucleic acid-binding, OB-fold