PF3D7_0812500

Genome location: Pf3D7_08_v3:625,465..630,796(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.98	0.27
Trophozoite	expressed	1.55	0.29
Schizont	expressed	0.51	0.71
Gametocyte	expressed	1.16	0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0812500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.66 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAW1

"Best" AlphaFill ligand hit: B3P (2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol, Local RMSD=5.20) with 5NFV (Global RMSD=27.84)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
5.2.1.8	peptidylprolyl isomerase	ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102469

Most Similar Human Ortholog: Q8WUA2

TM-align score: 0.35 | RMSD: 5.65

Seq Identity: 0.36 | Length: 225 / 958

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000131013	peptidylprolyl isomerase like 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	31	17	42
disruptive	17	80	57	135
missense	17	75	54	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	62	21	58
disruptive	33	185	92	219
missense	26	160	76	180

PlasmoDB Total SNPs: 194

Non-coding: 152 | Synonymous: 23 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 958 | Molecular Weight (kDa): 117.08

UniProt ID(s): Q8IAW1

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035542	Cyclophilin-RNA interacting protein
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily