Product Description: ubiquitin-conjugating enzyme E2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.2.23 (E2 ubiquitin-conjugating enzyme)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Function | GO:0061631 | ubiquitin conjugating enzyme activity |
Function | GO:0004842 | ubiquitin-protein transferase activity |
Process | GO:0006281 | DNA repair |
Process | GO:0016574 | histone ubiquitination |
Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
Process | GO:0000209 | protein polyubiquitination |
Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.07 | 0.97 |
Trophozoite | expressed | 0.16 | 0.89 |
Schizont | expressed | 0.05 | 0.96 |
Gametocyte | expressed | 0.44 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0812600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.344 | MFS: -2.606 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0806000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAW2
"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.62) with 4FH1 (Global RMSD=1.78)
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
2.3.2.23 | E2 ubiquitin-conjugating enzyme | CC0651[1,1'-biphenyl]-2-ol[1,1'-biphenyl]-2,2'-diol4-phenyl-1,3-thiazol-2-amine[1,1'-biphenyl]-2-sulfonamide5-chloro-1,3-benzoxazole-2-thiol6-chloro-1,3-benzoxazole-2-thiol1-(1,3-benzothiazol-2-yl)methanamine2-amino-5-phenylfuran-3-carbonitrile3-(2-hydroxyphenyl)pyridin-2(1H)-one3-methyl-3,4-dihydroquinazolin-2(1H)-one5,6-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione... |
Orthology to BindingDB Entries:
UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
---|---|---|---|---|
P63146 | Ubiquitin-conjugating enzyme E2 B | HOGENOM, OrthoDB | CHEMBL3787660 | |
P51965 | Ubiquitin-conjugating enzyme E2 E1 | OrthoDB | US9796725, Compound I-001US9796725, Compound I-098US9796725, Compound I-003US9796725, Compound I-004... | |
P61088 | Ubiquitin-conjugating enzyme E2 N | Homo sapiens | OrthoDB | MLS000074439MLS000032400MLS000041097MLS000055488... |
Ortholog Group (OrthoMCL): OG6_101178
Most Similar Human Ortholog: A0A0D9SG71
TM-align score: 0.98 | RMSD: 0.54
Seq Identity: 0.60 | Length: 119 / 163
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000077721 | ubiquitin conjugating enzyme E2 A |
ENSG00000119048 | ubiquitin conjugating enzyme E2 B |
Protein Length: 163 | Molecular Weight (kDa): 18.687
UniProt ID(s): Q8IAW2
PDB ID(s): None
Isoelectric Point: 7.24
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000608 | Ubiquitin-conjugating enzyme E2 |
InterPro | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
InterPro | IPR023313 | Ubiquitin-conjugating enzyme, active site |
PFam | PF00179 | Ubiquitin-conjugating enzyme E2 |
Superfamily | SSF54495 | Ubiquitin-conjugating enzyme/RWD-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 1 | 14 | 0 | 11 |
disruptive | 0 | 0 | 3 | 7 |
missense | 0 | 0 | 3 | 6 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 23 | 5 | 12 |
disruptive | 0 | 8 | 8 | 40 |
missense | 0 | 5 | 6 | 22 |
PlasmoDB Total SNPs: 88
Non-coding: 86 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |