Product Description: U1 small nuclear ribonucleoprotein C, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Function | GO:0003723 | RNA binding |
| Function | GO:0030627 | pre-mRNA 5'-splice site binding |
| Process | GO:0000395 | mRNA 5'-splice site recognition |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0812700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.658 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAW3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102948
Most Similar Human Ortholog: A0A0A0MRR7
TM-align score: 0.31 | RMSD: 4.03
Seq Identity: 0.29 | Length: 75 / 235
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124562 | small nuclear ribonucleoprotein polypeptide C |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 4 | 8 | 7 |
| disruptive | 7 | 18 | 10 | 26 |
| missense | 7 | 17 | 10 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 8 | 16 |
| disruptive | 13 | 33 | 26 | 42 |
| missense | 13 | 28 | 24 | 36 |
PlasmoDB Total SNPs: 109
Non-coding: 95 | Synonymous: 7 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 235 | Molecular Weight (kDa): 27.878
UniProt ID(s): Q8IAW3
PDB ID(s): None
Isoelectric Point: 8.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003604 | Matrin/U1-C-like, C2H2-type zinc finger |
| InterPro | IPR013085 | U1-C, C2H2-type zinc finger |
| InterPro | IPR017340 | U1 small nuclear ribonucleoprotein C |
| InterPro | IPR036236 | Zinc finger C2H2 superfamily |
| PFam | PF06220 | U1-C, C2H2-type zinc finger |
| Superfamily | SSF57667 | Zinc finger C2H2 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25897024 | Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, andSnp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNPsubunit Lea1 | Schwer B, Shuman S | 10.1261/rna.050583.115 |