About Gene List

PF3D7_0812800

Genome location: Pf3D7_08_v3:635,537..635,755(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.00 1.00
Trophozoite no data 0.01 1.00
Schizont no data 0.00 1.00
Gametocyte no data 0.01 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0812800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.528 | MFS: -2.635 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4U3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107357

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 2 0 4
disruptive 1 0 0 10
missense 1 0 0 8

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 3 1 6
disruptive 1 2 5 15
missense 1 1 5 8

PlasmoDB Total SNPs: 4

Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 72 | Molecular Weight (kDa): 8.44

UniProt ID(s): C0H4U3

PDB ID(s): None

Isoelectric Point: 10.3

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007513 Uncharacterised protein family SERF, N-terminal
InterPro IPR039438 At2g23090-like, zinc-binding domain
InterPro IPR039713 At2g23090-like
PFam PF04419 Uncharacterised protein family SERF, N-terminal
PFam PF12907 At2g23090-like, zinc-binding domain
Superfamily SSF118359 N/A

Associated Publications

No associated publications