PF3D7_0812900

Genome location: Pf3D7_08_v3:636,628..642,867(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.27	0.86
Trophozoite	not expressed	0.09	0.95
Schizont	not expressed	0.08	0.95
Gametocyte	expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0812900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.383 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAW4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139443

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	65	34	80
disruptive	46	118	76	127
missense	37	89	63	98

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	129	60	91
disruptive	87	222	93	251
missense	56	155	77	176

PlasmoDB Total SNPs: 240

Non-coding: 144 | Synonymous: 53 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1567 | Molecular Weight (kDa): 187.715

UniProt ID(s): Q8IAW4

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A