About Gene List

PF3D7_0813000 (KIC7)

Genome location: Pf3D7_08_v3:643,066..645,158(-)

Genome classification: Core

Function and Localization

Product Description: protein KIC7

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005829 cytosol
Process GO:0006897 endocytosis
Process GO:0009410 response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.55 0.38
Trophozoite not expressed 0.71 0.61
Schizont possibly expressed 0.50 0.70
Gametocyte not expressed 0.81 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0813000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.241 | MFS: -2.482 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1427200)

Modification: Disrupted | RMgm-1044

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K7Z9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533724

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 27 15 29
disruptive 25 44 27 76
missense 11 24 19 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 51 13 38
disruptive 43 102 50 135
missense 15 60 41 97

PlasmoDB Total SNPs: 114

Non-coding: 26 | Synonymous: 58 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 599 | Molecular Weight (kDa): 70.706

UniProt ID(s): A0A5K1K7Z9

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
31896710 A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malariaparasites. Birnbaum J, Scharf S, ..., Spielmann T 10.1126/science.aax4735