Product Description: CS domain protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0044310 | osmiophilic body |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0032502 | developmental process |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.50 | 0.70 |
| Schizont | expressed | 0.41 | 0.74 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0813200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -3.279 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAW7
"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=6.98) with 5EMH (Global RMSD=16.58)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106504
Most Similar Human Ortholog: Q8IVD9
TM-align score: 0.41 | RMSD: 4.23
Seq Identity: 0.19 | Length: 161 / 313
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000015676 | NudC domain containing 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 10 | 18 |
| disruptive | 9 | 23 | 17 | 31 |
| missense | 9 | 22 | 17 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 32 | 12 | 17 |
| disruptive | 15 | 46 | 24 | 60 |
| missense | 13 | 38 | 20 | 39 |
PlasmoDB Total SNPs: 158
Non-coding: 140 | Synonymous: 9 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 313 | Molecular Weight (kDa): 37.117
UniProt ID(s): Q8IAW7
PDB ID(s): None
Isoelectric Point: 6.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007052 | CS domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| InterPro | IPR025934 | NudC N-terminal domain |
| InterPro | IPR037898 | NudC family |
| PFam | PF04969 | CS domain |
| PFam | PF14050 | NudC N-terminal domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |