About Gene List

PF3D7_0813300

Genome location: Pf3D7_08_v3:655,382..658,303(+)

Genome classification: Core

Function and Localization

Product Description: NPL domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020020 food vacuole
Component GO:0005730 nucleolus
Component GO:0005634 nucleus
Function GO:0003723 RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 2.38 0.17
Trophozoite expressed 1.90 0.33
Schizont expressed 0.53 0.71
Gametocyte expressed 1.75 0.26

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0813300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.295 | MFS: -2.805 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4U4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120264

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 16 10 20
disruptive 11 31 16 38
missense 4 13 9 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 30 11 18
disruptive 27 58 38 83
missense 8 27 22 49

PlasmoDB Total SNPs: 129

Non-coding: 115 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 315 | Molecular Weight (kDa): 36.256

UniProt ID(s): C0H4U4

PDB ID(s): None

Isoelectric Point: 3.86

Protein Domain Annotations:

Source Family ID Description
InterPro IPR041232 Nucleoplasmin-like domain
PFam PF17800 Nucleoplasmin-like domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
21136929 Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, Tastet C, ..., Dubremetz JF 10.1002/prca.200700112
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21