Product Description: NPL domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020020 | food vacuole |
Component | GO:0005730 | nucleolus |
Component | GO:0005634 | nucleus |
Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 2.38 | 0.17 |
Trophozoite | expressed | 1.90 | 0.33 |
Schizont | expressed | 0.53 | 0.71 |
Gametocyte | expressed | 1.75 | 0.26 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0813300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.295 | MFS: -2.805 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4U4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 1 | 16 | 10 | 20 |
disruptive | 11 | 31 | 16 | 38 |
missense | 4 | 13 | 9 | 19 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 30 | 11 | 18 |
disruptive | 27 | 58 | 38 | 83 |
missense | 8 | 27 | 22 | 49 |
PlasmoDB Total SNPs: 129
Non-coding: 115 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 315 | Molecular Weight (kDa): 36.256
UniProt ID(s): C0H4U4
PDB ID(s): None
Isoelectric Point: 3.86
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR041232 | Nucleoplasmin-like domain |
PFam | PF17800 | Nucleoplasmin-like domain |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |