PF3D7_0813600

Genome location: Pf3D7_08_v3:668,841..671,366(+)

Genome classification: Core

Function and Localization

Product Description: translation initiation factor SUI1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003729	mRNA binding
Process	GO:0001731	formation of translation preinitiation complex
Process	GO:0002188	translation reinitiation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.56	0.75
Trophozoite	expressed	0.78	0.58
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0813600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.631 | MFS: -2.305 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAX2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102629

Most Similar Human Ortholog: O43583

TM-align score: 0.43 | RMSD: 4.54

Seq Identity: 0.29 | Length: 124 / 268

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000139726	density regulated re-initiation and release factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	13	1	18
disruptive	5	26	22	37
missense	5	25	21	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	22	11	12
disruptive	12	85	27	68
missense	9	69	21	35

PlasmoDB Total SNPs: 101

Non-coding: 77 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 268 | Molecular Weight (kDa): 31.351

UniProt ID(s): Q8IAX2

PDB ID(s): None

Isoelectric Point: 5.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001950	SUI1 domain
InterPro	IPR036877	SUI1 domain superfamily
PFam	PF01253	SUI1 domain
Superfamily	SSF55159	SUI1 domain superfamily