PF3D7_0813700 (ABCF1)

Genome location: Pf3D7_08_v3:670,741..675,700(-)

Genome classification: Core

Function and Localization

Product Description: ABC transporter F family member 1

SignalP Peptide: MFLELYFYLILCCYISFNSS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043190	ATP-binding cassette (ABC) transporter complex
Component	GO:0020011	apicoplast
Function	GO:0005524	ATP binding
Function	GO:0042626	ATPase-coupled transmembrane transporter activity
Process	GO:0006996	organelle organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.44	0.79
Trophozoite	expressed	0.98	0.50
Schizont	expressed	0.69	0.63
Gametocyte	expressed	0.90	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0813700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -3.192 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAX3

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.23) with 1G9X (Global RMSD=13.55)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533336

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	66	25	63
disruptive	52	148	77	197
missense	31	122	67	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	102	40	90
disruptive	88	275	122	284
missense	44	215	94	191

PlasmoDB Total SNPs: 211

Non-coding: 40 | Synonymous: 84 | Nonsynonymous: 87 | Stop Codon: 0

Protein Information

Protein Length: 1419 | Molecular Weight (kDa): 170.108

UniProt ID(s): Q8IAX3

PDB ID(s): None

Isoelectric Point: 6.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003439	ABC transporter-like
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00005	ABC transporter-like
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895