Product Description: DNA/RNA-binding protein Alba 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.97 | 0.25 |
| Trophozoite | expressed | 2.09 | 0.19 |
| Schizont | expressed | 0.57 | 0.68 |
| Gametocyte | expressed | 0.84 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0814200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.998 | MFS: -1.638 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAX8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101937
Most Similar Human Ortholog: Q8N5L8
TM-align score: 0.62 | RMSD: 2.94
Seq Identity: 0.31 | Length: 119 / 248
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164967 | ribonuclease P/MRP subunit p25 like |
| ENSG00000178718 | ribonuclease P and MRP subunit p25 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 274
Non-coding: 264 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 248 | Molecular Weight (kDa): 27.259
UniProt ID(s): Q8IAX8
PDB ID(s): None
Isoelectric Point: 11.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002775 | DNA/RNA-binding protein Alba-like |
| InterPro | IPR036882 | Alba-like domain superfamily |
| PFam | PF01918 | DNA/RNA-binding protein Alba-like |
| Superfamily | SSF82704 | Alba-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22167473 | PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malariaparasites. | Chene A, Vembar SS, ..., Scherf A | 10.1093/nar/gkr1215 |
| 26415947 | The PfAlba1 RNA-binding protein is an important regulator of translational timingin Plasmodium falciparum blood stages. | Vembar SS, Macpherson CR, ..., Scherf A | 10.1186/s13059-015-0771-5 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 21811616 | Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteinsthat interact with the translation machinery | Mani J, Guttinger A, ..., Roditi I | 10.1371/journal.pone.0022463 |
| 31185899 | Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi andortholog to the yeast SR-protein Gbp2 | Wippel HH, Malgarin JS, ..., Alves LR | 10.1186/s12866-019-1505-8 |