PF3D7_0814300

Genome location: Pf3D7_08_v3:690,182..694,542(-)

Genome classification: Core

Function and Localization

Product Description: AAA family ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0016887	ATP hydrolysis activity
Function	GO:1990275	preribosome binding
Process	GO:0051973	positive regulation of telomerase activity
Process	GO:0042254	ribosome biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.34	0.45
Trophozoite	expressed	0.71	0.62
Schizont	expressed	0.23	0.87
Gametocyte	expressed	0.48	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0814300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.837 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1423200)

Relative Growth Rate: nan ± nan
Confidence: 0.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAX9

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.07) with 4XGU (Global RMSD=5.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102053

Most Similar Human Ortholog: F8WF01

TM-align score: 0.46 | RMSD: 3.04

Seq Identity: 0.07 | Length: 45 / 1200

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000143748	nuclear VCP like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	42	37	61
disruptive	64	150	87	214
missense	51	130	76	194

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	105	64	88
disruptive	95	316	156	364
missense	71	258	139	266

PlasmoDB Total SNPs: 166

Non-coding: 45 | Synonymous: 49 | Nonsynonymous: 71 | Stop Codon: 1

Protein Information

Protein Length: 1200 | Molecular Weight (kDa): 139.669

UniProt ID(s): Q8IAX9

PDB ID(s): None

Isoelectric Point: 8.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR003960	ATPase, AAA-type, conserved site
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR041569	AAA ATPase, AAA+ lid domain
PFam	PF00004	ATPase, AAA-type, core
PFam	PF17862	AAA ATPase, AAA+ lid domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase