PF3D7_0814500

Genome location: Pf3D7_08_v3:699,666..703,075(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 1.4.3.4 (Monoamine oxidase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.60	0.42
Trophozoite	not expressed	0.28	0.85
Schizont	expressed	0.32	0.82
Gametocyte	not expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0814500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.144 | MFS: -2.768 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAY2

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
1.4.3.4	monoamine oxidase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144993

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	36	20	33
disruptive	28	136	64	158
missense	20	125	59	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	65	28	55
disruptive	56	284	128	317
missense	42	238	94	177

PlasmoDB Total SNPs: 171

Non-coding: 76 | Synonymous: 44 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 758 | Molecular Weight (kDa): 90.296

UniProt ID(s): Q8IAY2

PDB ID(s): None

Isoelectric Point: 9.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A