Product Description: structural integrity maintenance protein SIMP, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016020 | membrane |
| Process | GO:0071976 | cell gliding |
| Process | GO:0008360 | regulation of cell shape |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.00 | 1.00 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0814600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.997 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1422900)
Modification: Tagged | RMgm-5195
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAY3
"Best" AlphaFill ligand hit: TSN (trichostatin a, Local RMSD=3.57) with 5EEK (Global RMSD=16.86)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 29 | 18 | 14 |
| disruptive | 0 | 10 | 15 | 26 |
| missense | 0 | 10 | 11 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 50 | 9 | 20 |
| disruptive | 3 | 46 | 17 | 78 |
| missense | 2 | 33 | 14 | 49 |
PlasmoDB Total SNPs: 18
Non-coding: 0 | Synonymous: 17 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 393 | Molecular Weight (kDa): 44.847
UniProt ID(s): Q8IAY3
PDB ID(s): None
Isoelectric Point: 7.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 33791240 | Identification of Three Novel Plasmodium Factors Involved in Ookinete to OocystDevelopmental Transition. | Ukegbu CV, Christophides GK, Vlachou D | 10.3389/fcimb.2021.634273 |
| 35301756 | A conserved Plasmodium structural integrity maintenance protein (SIMP) isassociated with sporozoite membrane and is essential for maintaining shape andinfectivity. | Singh D, Patri S, ..., Kumar KA | 10.1111/mmi.14894 |