PF3D7_0814700

Genome location: Pf3D7_08_v3:705,804..707,350(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.25	0.87
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.11	0.93
Gametocyte	expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0814700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.6 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1422800)

Modification: Disrupted | RMgm-4297

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAY4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533197

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	15	8	12
disruptive	15	29	27	64
missense	13	27	25	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	25	11	14
disruptive	27	77	44	88
missense	18	64	42	63

PlasmoDB Total SNPs: 73

Non-coding: 31 | Synonymous: 23 | Nonsynonymous: 17 | Stop Codon: 2

Protein Information

Protein Length: 306 | Molecular Weight (kDa): 35.462

UniProt ID(s): Q8IAY4

PDB ID(s): None

Isoelectric Point: 10.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A