Product Description: superoxide dismutase [Fe]
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.15.1.1 (Superoxide dismutase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0005515 | protein binding |
| Function | GO:0004784 | superoxide dismutase activity |
| Process | GO:0006979 | response to oxidative stress |
| Process | GO:0006801 | superoxide metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.38 | 0.76 |
| Schizont | expressed | 0.16 | 0.89 |
| Gametocyte | expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0814900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.311 | MFS: -3.416 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1422700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1422700)
Modification: Disrupted | RMgm-3850
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9TW89
"Best" AlphaFill ligand hit: PMS (phenylmethanesulfonic acid, Local RMSD=0.05) with 1WB8 (Global RMSD=4.99)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.15.1.1 | superoxide dismutase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q4DCQ3 | Superoxide dismutase | OrthoDB | CHEMBL4127450CHEMBL4128846CHEMBL4129006 |
Ortholog Group (OrthoMCL): OG6_100280
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 198
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112096 | superoxide dismutase 2 |
Protein Length: 198 | Molecular Weight (kDa): 22.734
UniProt ID(s): Q8IAY6, Q95034, Q9TW89
PDB ID(s): 2BPI
Isoelectric Point: 6.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| InterPro | IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
| InterPro | IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
| InterPro | IPR019833 | Manganese/iron superoxide dismutase, binding site |
| InterPro | IPR036314 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
| InterPro | IPR036324 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| PFam | PF00081 | Manganese/iron superoxide dismutase, N-terminal |
| PFam | PF02777 | Manganese/iron superoxide dismutase, C-terminal |
| Superfamily | SSF46609 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| Superfamily | SSF54719 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 3 | 11 |
| disruptive | 2 | 3 | 3 | 10 |
| missense | 2 | 3 | 1 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 3 | 4 |
| disruptive | 2 | 11 | 13 | 33 |
| missense | 2 | 8 | 12 | 22 |
PlasmoDB Total SNPs: 75
Non-coding: 64 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15279958 | Identification of a mitochondrial superoxide dismutase with an unusual targetingsequence in Plasmodium falciparum. | Sienkiewicz N, Daher W, ..., Khalife J | 10.1016/j.molbiopara.2004.05.005 |
| 17020617 | The crystal structure of superoxide dismutase from Plasmodium falciparum. | Boucher IW, Brzozowski AM, ..., Wilkinson AJ | 10.1186/1472-6807-6-20 |
| 24494818 | A secretory multifunctional serine protease, DegP of Plasmodium falciparum, playsan important role in thermo-oxidative stress, parasite growth and development. | Sharma S, Jadli M, ..., Malhotra P | 10.1111/febs.12732 |
| 25091832 | Molecular cloning and biochemical characterization of iron superoxide dismutasefrom the rodent malaria parasite Plasmodium vinckei. | Prakash K, Goyal M, ..., Puri SK | 10.1016/j.parint.2014.07.004 |
| 36678771 | Identification of Aryl Polyamines Derivatives as Anti-Trypanosoma cruzi AgentsTargeting Iron Superoxide Dismutase | Martin-Escolano R, Molina-Carreno D, ..., Marin C | 10.3390/pharmaceutics15010140 |
| 37217925 | Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosomacruzi populations | Lima DA, Goncalves LO, ..., Murta SMF | 10.1186/s13071-023-05775-4 |