About Gene List

PF3D7_0815000 (SEL3)

Genome location: Pf3D7_08_v3:709,033..711,020(-)

Genome classification: Core

Function and Localization

Product Description: selenoprotein 3

SignalP Peptide: MILKKVYILIILILLSILSRTVDS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus
Process GO:0045454 cell redox homeostasis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite expressed 0.55 0.69
Schizont possibly expressed 0.04 0.97
Gametocyte possibly expressed 0.26 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0815000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.267 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532847

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 11 10 17
disruptive 4 23 18 44
missense 4 22 17 40

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 19 13 22
disruptive 14 60 29 52
missense 9 52 26 44

PlasmoDB Total SNPs: 86

Non-coding: 67 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 351 | Molecular Weight (kDa): 41.559

UniProt ID(s): C0Z3M4

PDB ID(s): None

Isoelectric Point: 10.16

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16428245 The Plasmodium selenoproteome. Lobanov AV, Delgado C, ..., Gladyshev VN 10.1093/nar/gkj450
22229886 Insight into the selenoproteome of the malaria parasite Plasmodium falciparum. Roseler A, Prieto JH, ..., Becker K 10.1089/ars.2011.4276