PF3D7_0815100

Genome location: Pf3D7_08_v3:711,239..714,166(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat and RAP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.93
Trophozoite	not expressed	0.20	0.88
Schizont	not expressed	0.06	0.96
Gametocyte	possibly expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0815100

Resistome Missense Mutations: L438F

Resistome Compounds with Missense Mutations: MMV019662

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.072 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1422500)

Relative Growth Rate: 0.06 ± 0.04
Confidence: 8.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAY8

"Best" AlphaFill ligand hit: BTN (biotin, Local RMSD=7.22) with 2EJ9 (Global RMSD=17.43)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126356

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	38	30	65
disruptive	41	157	73	173
missense	27	134	71	148

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	88	45	58
disruptive	84	300	96	269
missense	51	251	79	204

PlasmoDB Total SNPs: 90

Non-coding: 0 | Synonymous: 40 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 975 | Molecular Weight (kDa): 115.891

UniProt ID(s): Q8IAY8

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A