PF3D7_0815200

Genome location: Pf3D7_08_v3:715,597..720,744(+)

Genome classification: Core

Function and Localization

Product Description: importin subunit beta, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005643	nuclear pore
Component	GO:0005634	nucleus
Function	GO:0061608	nuclear import signal receptor activity
Function	GO:0008139	nuclear localization sequence binding
Process	GO:0006607	NLS-bearing protein import into nucleus
Process	GO:0006606	protein import into nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.22	0.89
Trophozoite	possibly expressed	0.30	0.81
Schizont	not expressed	0.10	0.93
Gametocyte	not expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0815200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.067 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1422400)

Relative Growth Rate: 0.11 ± 0.71
Confidence: 2.06

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAY9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101642

Most Similar Human Ortholog: Q14974

TM-align score: 0.89 | RMSD: 2.97

Seq Identity: 0.27 | Length: 841 / 877

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000108424	karyopherin subunit beta 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	79	39	36
disruptive	1	16	13	35
missense	1	13	8	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	124	21	43
disruptive	7	44	30	124
missense	4	30	18	67

PlasmoDB Total SNPs: 216

Non-coding: 194 | Synonymous: 20 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 877 | Molecular Weight (kDa): 99.964

UniProt ID(s): Q8IAY9

PDB ID(s): None

Isoelectric Point: 4.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001494	Importin-beta, N-terminal domain
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR040122	Importin beta family
PFam	PF03810	Importin-beta, N-terminal domain
PFam	PF13513
Superfamily	SSF48371	Armadillo-type fold