PF3D7_0815400 (ATPTG3)

Genome location: Pf3D7_08_v3:725,500..726,860(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0815400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.166 | MFS: -2.755 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0715400)

Relative Growth Rate: 0.86 ± 0.15
Confidence: 5.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0715400)

Modification: Disrupted | RMgm-2249

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAZ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134712

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	3	15
disruptive	2	13	11	15
missense	2	13	11	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	13	8	8
disruptive	4	30	16	25
missense	4	27	14	20

PlasmoDB Total SNPs: 84

Non-coding: 79 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 160 | Molecular Weight (kDa): 18.787

UniProt ID(s): Q8IAZ1

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
27594426	A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes.	Sidik SM, Huet D, ..., Lourido S	10.1016/j.cell.2016.08.019
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21